Find and compare cruises to the Panama Canal from Los Angeles, California in 2025 on Cruisebound. Search the best cruise deals, including last-minute deals.

Book cruises to the Panama Canal from Los Angeles, California in 2025 Online and Save

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53 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru, Coquimbo (La Serena), Chile, San Antonio, Chile, Puerto Montt, Chile, Chacabuco, Chile, Amalia (Skua) Glacier, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Cape Horn (scenic Cruising), Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina, Buenos Aires, Argentina, Buenos Aires, Argentina, Punta Arenas, Chile, Ushuaia, Argentina, Antarctic Peninsula, Antarctica, Antarctic Peninsula, Antarctica, Antarctic Peninsula, Antarctica, Antarctic Peninsula, Antarctica, Stanley, Falkland Islands, Montevideo, Uruguay and Buenos Aires, Argentina, starting at 6958.0 per person.

53 Night South America Cruise

36 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru, Coquimbo (La Serena), Chile, San Antonio, Chile, Puerto Montt, Chile, Chacabuco, Chile, Amalia (Skua) Glacier, Chile, Punta Arenas, Chile, Ushuaia, Argentina, Cape Horn (scenic Cruising), Stanley, Falkland Islands, Puerto Madryn, Argentina, Montevideo, Uruguay, Buenos Aires, Argentina and Buenos Aires, Argentina, starting at 3898.0 per person.

36 Night South America Cruise

12 Night Panama Canal Cruise aboard the Regatta departing from Los Angeles, California, on 2025-11-02, cruises to Ensenada, Mexico, Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Corinto, Nicaragua, Puntarenas, Costa Rica, Panama Canal Daylight Transit and Colon, Panama, starting at 2590.0 per person.

12 Night Panama Canal Cruise

20 Night South America Cruise aboard the Sapphire Princess departing from Los Angeles, California, on 2025-11-16, cruises to Manzanillo, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Manta (Quito), Ecuador, Callao (Lima), Peru, Callao (Lima), Peru, Pisco (Puerto San Martin), Peru and Coquimbo (La Serena), Chile, starting at 1998.0 per person.

20 Night South America Cruise

27 Night Caribbean - Southern Cruise aboard the Grand Princess departing from Los Angeles, California, on 2025-09-15, cruises to Manzanillo, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean, Fort Lauderdale (Port Everglades), Florida, Grand Turk, Turks and Caicos, Amber Cove, Dominican Republic, Kralendijk, Bonaire, Dutch Antilles, Curacao, Caribbean, Port of Oranjestad, Aruba, Caribbean, Port of Basseterre, St. Kitts, St. Kitts and Nevis, St. Thomas, U.S. Virgin Islands and San Juan, Puerto Rico, starting at 1358.0 per person.

27 Night Caribbean - Southern Cruise

18 Night Transcanal Cruise aboard the Island Princess departing from Los Angeles, California, on 2025-05-17, cruises to Puerto Vallarta, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit Historic Locks, Port of Oranjestad, Aruba, Caribbean and New York, New York, starting at 1349.0 per person.

18 Night Transcanal Cruise

16 Night Repo aboard the Norwegian Encore departing from Los Angeles, California, on 2025-10-23, cruises to Cabo San Lucas, Mexico, Puerto Vallarta, Mexico, Manzanillo, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera, Costa Rica, Panama City, Panama, Panama Canal, Panama, Cartagena, Colombia and Miami, Florida, starting at 1138.57 per person.

16 Night Repo

15 Night Repo aboard the Norwegian Joy departing from Los Angeles, California, on 2025-10-05, cruises to Cabo San Lucas, Mexico, Acapulco, Mexico, Puerto Quetzal, Guatemala, Puerto Caldera, Costa Rica, Panama City, Panama, Panama Canal, Panama, Cartagena, Colombia and Miami, Florida, starting at 1049.0 per person.

15 Night Repo

16 Night Panama Canal Eastbound Cruise aboard the Celebrity Summit departing from Los Angeles, California, on 2025-09-19, cruises to Puerto Vallarta, Mexico, Puerto Barrios, Guatemala, Puntarenas, Costa Rica, Panama Canal, Panama, Cartagena, Colombia, Falmouth, Jamaica, Georgetown, Grand Cayman, Cayman Islands and Fort Lauderdale (Port Everglades), Florida, starting at 898.0 per person.

16 Night Panama Canal Eastbound Cruise

16 Night Transcanal Cruise aboard the Grand Princess departing from Los Angeles, California, on 2025-09-15, cruises to Manzanillo, Mexico, Huatulco, Mexico, Puerto Chiapas, Mexico, Puntarenas, Costa Rica, Fuerte Amador, Panama, Panama Canal Full Transit New Locks, Port of Oranjestad, Aruba, Caribbean and Fort Lauderdale (Port Everglades), Florida, starting at 549.0 per person.

16 Night Transcanal Cruise

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Princess Cruises

Norwegian Cruise Line

Celebrity Cruises

Oceania Cruises

Viking Ocean Cruises

Browse Cruise Lines

Sapphire Princess

Grand Princess

Island Princess

Coral Princess

Caribbean Princess

Browse Cruise Ships

Los Angeles, California

Manzanillo, Mexico

Puntarenas, Costa Rica

Fuerte Amador, Panama

Manta (Quito), Ecuador

Callao (Lima), Peru

Pisco (Puerto San Martin), Peru

Coquimbo (La Serena), Chile

San Antonio, Chile

Puerto Montt, Chile

Chacabuco, Chile

Amalia (Skua) Glacier, Chile

Punta Arenas, Chile

Ushuaia, Argentina

Cape Horn (scenic Cruising)

Stanley, Falkland Islands

Puerto Madryn, Argentina

Montevideo, Uruguay

Buenos Aires, Argentina

Antarctic Peninsula, Antarctica

Ensenada, Mexico

Cabo San Lucas, Mexico

Acapulco, Mexico

Puerto Quetzal, Guatemala

Puerto Corinto, Nicaragua

Panama Canal Daylight Transit

Colon, Panama

Regatta

Huatulco, Mexico

Puerto Chiapas, Mexico

Panama Canal Full Transit New Locks

Port of Oranjestad, Aruba, Caribbean

Fort Lauderdale (Port Everglades), Florida

Grand Turk, Turks and Caicos

Amber Cove, Dominican Republic

Kralendijk, Bonaire, Dutch Antilles

Curacao, Caribbean

Port of Basseterre, St. Kitts, St. Kitts and Nevis

St. Thomas, U.S. Virgin Islands

San Juan, Puerto Rico

Puerto Vallarta, Mexico

Panama Canal Full Transit Historic Locks

New York, New York

Puerto Caldera, Costa Rica

Panama City, Panama

Panama Canal, Panama

Cartagena, Colombia

Miami, Florida

Norwegian Encore

Norwegian Joy

Puerto Barrios, Guatemala

Falmouth, Jamaica

Georgetown, Grand Cayman, Cayman Islands

Celebrity Summit

Panama Canal